santiago de chile | octubre, 1985







ABSTRACT

Nitric oxide is a multifunctional signaling molecule, intricately involved with mantaining a host of physiological processes including but not limited to host defense, neuronal communication and the regulation of vascular tone. Many of the physiological functions first ascribed to NO are mediated through its primary receptor, soluble guanylyl cyclase. Endogenous production of NO is a highly complex and regulated process involving the 5-electron oxidation of L-arginine, requiring numerous substrates and cofactors. The production of a highly reactive and diffusible free radical gas further complicates our established concept and model of specific and targeted receptor-ligand interaction to elicit cell signaling events. Hence there are many steps in the endogenous pathway for altered production of NO and subsequent activation of sGC that may be targets for drug development as well as other molecular targets for NO. The following review will highlight the current state of the art of NO-sGC research and illustrate disease processes which may benefit from novel drug development exploiting the NO-sGC pathway as well as NOS & cGMP-independent pathways.

NS Bryan, K Bian & F Murad (2009) Front Biosci 14:1-18.







época de recesos.
quizás vuelvan las oscuras (y muy antiguas) golondrinas en reemplazo de lo que se va.